Wednesday, January 31, 2007
A woman, one of three people who recently died of flu like symptoms, in Lagos, Nigeria, has tested positive for the H5N1 strain of Avian influenza.
It is the first bird flu in Nigeria since the strain arrived in Nigeria a year ago. H5N1 was confirmed in blood samples tested in Rome and London from the three recent deaths.
The Food and Agriculture Organization of the United Nations stated that while the threat from avian flu has decreased from last year, there still remains flare-ups around the world, urging countries to “remain vigilant and fully cooperate with international organizations”.
Bird flu is spread by wild birds for whom the virus is a stomach disease and, generally, not fatal.
Although the disease has killed 164 people, it has only been out of 269 cases, this gives the disease around a 60% fatality rate compared to the 1918 ‘Spanish flu’ pandemic which had a mortality rate of around 5%.
The outer coat of the virus particle is characterised by two types of glyco-proteins, neurominidase and haemagglutinin, both of which interact with sialic acid.
Haemagglutinin has sixteen forms, H1 to H16, and binds to sialic acid on the target cell, facilitating the entry of the virus.
Neurominidase is found in nine forms, N1 to N9, this protein allows the progeny viri to escape the infected cell by cleaving sialic acid.
The two main drugs against bird flu currently on the market, Tamiflu® and Relenza®, both target the sialic acid binding pocket of neurominidase. Neither of these drugs will cure the disease, but will stop its spread through the body. As such they have to be administered within 48 hours of symptoms appearing. In all 9 sub types of neurominidase, the structure of the target area for the drugs is the same. There is also a flu vaccine but the current flu vaccine does not protect against H5N1.
Human to human transmission is very rare, at the moment bird flu can only be caught from prolonged exposure to infected birds, specifically their droppings from which the bird flu virus has been crystallized and parts of the structure solved.
Unlike diseases such as smallpox and measles, for which their are effectively protecting vaccines, the flu virus constantly mutates. Each year the virus is slightly different from the last, this is the genetic drift of the virus – small point mutations on the surface, causing an evasion of our immune system. Many of the problems arise when there is a major shift of the surface proteins, for instance when a different subtype appears, such as H5.
There are three strains of human influenza circulating around the globe; H1N1 first isolated in 1933, H2N2 first isolated in 1957 and H3N2 first isolated in 1968. Other than humans; pigs, seals and horses have various strains of influenza, however only wild birds have all the known subtypes of haemagglutinin and neurominidase. Of the 144 combinations of N(1-9) and H(1-16) we have had three.
- Click Here For More Specific Information On:
- Building Management Services Sydney
Submitted by: Daniela Rivero
You’ve heard about the new DMXReady CMS v2. You’ve tried the online demos. Now you can try your very own lite version right on your own server!
This month, DMXReady introduced CMS (Lite) v2, the free version of our flagship application. This gives you all (well okay, most) of the power of the full version, with certain limitations like number of pages and a lock on some of the advanced features.
However it still has most of the functionality like:
Create Customizable URLs Skin Using WordPress Themes & other 3rd Party Website Templates Plugin DMXReady v2 Apps & Accessories W3C Valid CSS & XHTML Add Gadgets and Widgets (Google, Facebook, Youtube etc.) Built-in SEO so that your website gets found easier Pre-built database already installed! In other words, this is a great way to try DMXReady CMS before you buy. And if you are looking for an inexpensive way to get a small CMS website up and running fast, DMXReady CMS v2 is the choice for you! How to use: There are 3 ways to use DMXReady CMS (Lite) v2 application: Stand Alone Usage – can run outside your website as a separate link.
Plug In Use – can run inside an existing web page from your website.
Inside a Template – can copy/paste page components (header, details, navigation, search, footer) into your 3rd party CSS/Web 2.0 website templates or Joomla, WordPress, Drupal themes.
It’s remarkable — in almost every industry, technology drives the way people work just as much as vice versa. In the publishing world for example, people went from laying down typeset scrolls of text onto page mockups to designing everything directly on the computer. But it didn’t happen overnight. In fact it took about a decade for people “get with the times” and catch up with the technology.
The same is true in website design. Yes, there have been tweaks to the technology but HTML and coding languages like ASP have been with us for over 10 years now, and we are still finding new ways of using it.
So it is too with DMXReady’s v2 applications. These apps will do many of the same things our first generation applications did just faster and better. Our v2 apps give you a whole new level of control and a whole new realm of possibilities.
Most importantly, these v2 applications will make it easier for your clients to own and maintain their websites, taking CMS to another level.
So what’s new for DMXReady v2 apps?
Simplified Architecture for Better Plugin Integration Clean, Compliant, Commented Code – W3C Valid CSS & XHTML Cross-Browser Compatibility Efficient Use of AJAX Scripting & JQuery To Enhance Usability Built-In code editor for CSS, Code, Templates and More – no need for HTML editor SEO Friendly URL’s – Create Custom URLs automatically. DMXReady v2 applications will improve the way that you design websites, giving you power and ease of use like you’ve never had before.
Take a look at DMXReady CMS to see how! http://testserver.dmxready.com/
Then check out our growing list of v2 applications: http://www.dmxready.com/products.asp
Download a copy for yourself and check it out! Download here: http://www.dmxready.com/dmxreadyv2/index.asp?page=catalog&product=cms-lite
Until next time,
The DMXReady Team
About the Author:
dmxready.com
Source:
isnare.com
Permanent Link:
isnare.com/?aid=433658&ca=Opinions
Sunday, January 21, 2007
Ricky “The Hitman” Hatton regained the IBF light welterweight title belt he relinquished less than 12 months ago when he defeated Juan Urango in Las Vegas, Nevada tonight.
“The Hitman” won by unanimous decision, as the fight went to 12 rounds. Despite early match odds suggesting Hatton would dominate the fight, this was not the case. Each round was close, but most pundits and judges alike agreed that Urango only won 1 of the 12 rounds, with Hatton taking the other 11.
Despite the unfamiliar confines of Las Vegas, Hatton looked touched by the ringing of football fan-like chants, familiar in British boxing, that rang around the arena, as more than half of it was filled by traveling support from across the atlantic.
Many in the UK will hope Hatton has ended the “curse” that has seen names such as Frank Bruno, Naseem Hamed, Barry McGuigan and others fall short while headlining fights on “The Strip”.
From here, it is widely believed “The Hitman” will move on to fight Jose Luis Castillo in June, again likely in Vegas.